Majority of the proteins are the most variable and highly specialized enzymes. Acting as organic catalysts, they accelerate metabolic reactions. Virtually, every type of metabolic reaction is driven by a particular or specific type of enzyme. Hence, metabolic reactions of thousands of different kinds in every cell require enzymes of thousands of different kinds. In fact, the basis of the phenotypic expression of every hereditary characteristic is a specific type of metabolic reaction which in turn, is driven by a specific type of enzyme. Synthesis of defective or abnormal enzymatic proteins, therefore, forms the basis of genetic diseases. About 1400 such diseases are known in case of human beings.