Multiple choice

A feature of a Salmonella-based vaccine expressing antigens from other infectious agents is that

  1. immunity is limited to the gut

  2. only secretory IgA is elicited

  3. it does not invade the mucosal lining of the gut

  4. it provokes both oral and systemic immunity

  5. the organism does not need to be attenuated
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D Correct answer
Explanation

Salmonella infects cells of the mononuclear phagocyte system throughout the body and thereby stimulates the production of cell-mediated immunity, in addition to both secretory and systemic antibody production. It can be made to express proteins from shigella, cholera, malarial sporozoites, etc and has potential as an orally administered vaccine.

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