Multiple choice

A potential disadvantage of immunological protection using passive transfer of horse globulins is

  1. irreversible protection

  2. lack of antibody-mediated immune response

  3. type IV hypersensitivity reactions

  4. immunodeficiency

  5. serum sickness
Reveal answer Fill a bubble to check yourself
E Correct answer
Explanation

Horse globulins containing anti-tetanus and anti-diphtheria toxins have been extensively employed prophylactically, but have the drawback that serum sickness develops in response to foreign proteins, producing vasculitic skin rashes, swollen joints and transient albuminuria due to immune complex-mediated inflammatory reactions.

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