Multiple choice

Which of the following statements regarding the pathogenesis of rickettsiae is INCORRECT?

  1. Rickettsiae grow free in the cytoplasm of cultured cells.

  2. Rickettsiae gets propelled by the host cell cytoplasm.

  3. Propulsion by F-actin helps in the spread of rickettsiae to adjacent endothelial cells.

  4. Growth of rickettsiae in the endothelium leads the damage of vascular integrity of an individual.

  5. Fusion of lysosomes with thrombocytes results in the digestion of dying rickettsia.
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E Correct answer
Explanation

Gamma interferon and tumor necrosis factor alpha secreted by host immune cells activates the infected endothelial cell to destroy intracellular rickettsiae by the creation of autophagosomes. Later, fusion of lysosomes with autophagosomes results in the digestion of dying rickettsia  .

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