Multiple choice Crossing over occurs between two sister chromatids of the same chromosome two non- sister chromatids of the same chromosome two non-sister chromatids of the homologous chromosome two sister chromatids of the homologous chromosome Reveal answer Fill a bubble to check yourself C Correct answer Explanation Crossing over occurs between non-sister chromatids of homologous chromosomes (one maternal, one paternal). Sister chromatids are identical copies and do not exchange genetic material with each other.