Multiple choice

Which of the following is associated with maximum risk of invasive carcinoma of cervix?

  1. Low grade squamous intraepithelial lesion

  2. High grade squamous intraepithelial lesion

  3. Squamous intraepithelial lesion associated with HPV-16

  4. Squamous intraepithelial lesion associated with HIV
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

HPV-16 is the highest-risk oncogenic type for cervical cancer progression. High-grade SIL carries more risk than low-grade, but HPV-16 positivity (whether in low or high-grade lesions) confers the greatest risk of progression to invasive carcinoma. HIV increases risk but HPV-16 is the direct driver.

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