Multiple choice

The BEST agent used for fixation of Pap smear is

  1. ethyl alcohol

  2. acetone

  3. formalin

  4. xylol
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

Ethyl alcohol (95% ethanol) is the standard fixative for Pap smears. It rapidly fixes cells, preserves cellular morphology, and prevents artifact formation. The smear should be immersed in alcohol immediately after collection or sprayed with fixative. Acetone is a dehydrant but not ideal for cytology. Formalin causes shrinkage artifacts. Xylol is a clearing agent used in histology processing, not for cytology fixation.

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