Multiple choice

Marker for acute Hepatitis B is

  1. HBV-DNA polymerase

  2. IgG anti-HBc

  3. core antigen (HbcAg)

  4. Anti-HbsAg
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A Correct answer
Explanation

HBV-DNA polymerase is the earliest and most specific marker of acute Hepatitis B infection, appearing during the incubation period before symptoms and serological markers. IgG anti-HBc indicates past infection. Core antigen (HBcAg) is intracellular and not detected in serum. Anti-HBs appears later during recovery and indicates immunity. HBV-DNA polymerase is the best marker for acute infection.

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