Multiple choice

In collapsing glomerulopathy, which of the following is seen?

  1. Hypertrophy and degeneration of the visceral epithelium

  2. Proliferation of the parietal epithelium

  3. Tuft necrosis

  4. Mesangiolysis
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Explanation

Collapsing glomerulopathy is a pattern of glomerular injury characterized by severe segmental or global collapse of the glomerular capillary loops. The key histological feature is hypertrophy and hyperplasia of the visceral epithelial cells (podocytes) overlying the collapsed segments. This is quite distinct from parietal epithelial proliferation (crescents), tuft necrosis, or mesangiolysis which are features of other glomerular diseases.

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