Multiple choice

Which one of the following does not act via GABA A?

  1. Thiopentone

  2. Midazolam

  3. Zolpidem /zopiclone

  4. Promethazine

Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Thiopentone, midazolam, and zolpidem/zopiclone all act as positive allosteric modulators at the GABA-A receptor complex to produce their sedative-hypnotic effects. Promethazine is a first-generation antihistamine that primarily acts by blocking H1 receptors, not through GABA-A mechanisms.