Multiple choice

OC pills are contraindicated in patients receiving

  1. rifampicin

  2. ethambutol

  3. streptomycin

  4. pyrazinamide
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A Correct answer
Explanation

Rifampicin is a potent hepatic enzyme inducer that accelerates estrogen metabolism in OC pills, reducing their contraceptive efficacy and increasing failure risk. This is a clinically important drug interaction. Other anti-TB drugs listed (ethambutol, streptomycin, pyrazinamide) don't significantly interact with OCs.

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