Multiple choice

A 2-year old child presents with scattered lesions in the skull. Biopsy revealed Langerhans giant cells. Most commonly associated is:

  1. CD1a

  2. CD57

  3. CD3

  4. CD68

Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

Langerhans Cell Histiocytosis (LCH) is characterized by proliferation of Langerhans cells, which are dendritic cells that normally reside in skin and lymph nodes. These cells pathologically express CD1a, which is a specific immunohistochemical marker for LCH diagnosis. CD57 is typically associated with NK cells, CD3 with T-cells, and CD68 with macrophages.