Multiple choice

A 2-year old child is presented with scattered lesions in the skull. Biopsy has revealed Langerhans giant cells. Which of the following is most commonly associated?

  1. CD1a

  2. CD57

  3. CD3

  4. CD68

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A Correct answer
Explanation

Langerhans Cell Histiocytosis (LCH) is characterized by proliferation of Langerhans cells which express CD1a as a specific surface marker. CD1a is considered the most specific immunohistochemical marker for LCH. CD57 is found on NK cells, CD3 on T-cells, and CD68 on macrophages/monocytes.