Multiple choice

Which of the following statements are false regarding gluconeogenesis? P. Gluconeogenesis begins in the mitochondria with the formation of oxaloacetate by the carboxylation of pyruvate. Q. Malate is oxidised to oxaloacetate using NAD+ in the mitochondria. R. Glucose-6-phosphate is formed from fructose 6-phosphate by phosphoglucoisomerase. S. In final step of gluconeogenesis, the formation of glucose occurs in the cisternae of the Golgi apparatus. Select the correct answer using codes given below:

  1. P and Q

  2. P and R

  3. Q and R

  4. Q and S

  5. R and S
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Malate is oxidised to oxaloacetate using NAD+ in the cytosol. In the final reaction of gluconeogenesis, glucose-6-phosphate is hydrolysed by glucose-6-phosphatase to produce glucose. It occurs in the lumen of the endoplasmic reticulum.

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