Multiple choice Two functions of rough endoplasmic reticulum are to modify and activate hormones join with and hydrolyze food vacuoles detoxify and transport drugs synthesize and transport enzymes Reveal answer Fill a bubble to check yourself D Correct answer Explanation Rough ER has ribosomes attached to its surface, giving it its 'rough' appearance. These ribosomes synthesize proteins (including enzymes), which the rough ER then transports to the Golgi apparatus. Smooth ER detoxifies drugs, not rough ER.