Multiple choice A cell is made of living substance called _____. cytoplasm protoplasm gene deoxyribonucleic acid Reveal answer Fill a bubble to check yourself B Correct answer Explanation Protoplasm is the living substance that makes up a cell, consisting of cytoplasm, nucleus, and other organelles. Cytoplasm is just the gel outside the nucleus, gene is a unit of heredity, and DNA is the genetic material within the nucleus.