Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. It binds to GABA receptors (GABA-A and GABA-B) causing hyperpolarization of neurons by opening chloride channels, reducing neuronal excitability. Adrenaline is excitatory, acetylcholine can be excitatory at neuromuscular junctions, and histamine has various effects including excitatory roles in arousal and wakefulness.