Multiple choice

Which of the following events do(es) not occur during the regulation of fatty acid metabolism?

P. Malonyl-CoA inhibits carnitine acyltransferase. Q. 3-hydroxyacyl-CoA dehydrogenase inhibits NADH to NAD+ conversion. R. Thiolase is inhibited by acetyl-CoA.

  1. Only P

  2. Only Q

  3. Only R

  4. P and Q

  5. Q and R
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

Regulation of fatty acids metabolism: Acyl-CoA movement into the mitochondrion is a crucial factor in regulation. Malonyl-CoA which is present in the cytoplasm in high amounts when metabolic fuels are abundant, inhibits carnitine acyltransferase, thereby preventing acyl-CoA from entering the mitochondrion. Furthermore, 3-hydroxyacyl-CoA dehydrogenase is inhibited by NADH and thiolase is inhibited by acetyl-CoA, so that fatty acids wil not be oxidized when there are plenty of energy-yielding substrates in the cell. Hence, only the statement Q is false.

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