Multiple choice

Uniparental disomy for chromosome 15 in which both chromosomes are maternally derived is associated with which of the following syndromes?

  1. Prader–Willi syndrome

  2. Angelman syndrome

  3. Rett syndrome

  4. Beckwith-Wiedemann syndrome

  5. Cystic fibrosis

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A Correct answer
Explanation

Maternal uniparental disomy (UPD) for chromosome 15 results in Prader–Willi syndrome; paternal UPD would lead to Angelman syndrome.