Multiple choice

In which of the following reactions, primary or secondary amine is methylated using excess formic acid and formaldehyde?

  1. The Aza Diels-Alder reaction

  2. The Baylis-Hillman reaction

  3. The Eschweiler-Clarke reaction

  4. The Amadori Rearrangement

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C Correct answer
Explanation

The Eschweiler-Clarke reaction is a chemical reaction whereby a primary (or secondary) amine is methylated using excess formic acid and formaldehyde. Reductive amination reactions such as this one will not produce quaternary ammonium salts, but instead will stop at the tertiary amine stage.