Multiple choice general knowledge Where did the deadliest natural disaster in US history take place? Texas. Washington state. Arkansas. Florida. Reveal answer Fill a bubble to check yourself A Correct answer Explanation The 1900 Galveston hurricane in Texas remains the deadliest natural disaster in U.S. history, killing approximately 6,000-12,000 people. This Category 4 hurricane struck Galveston Island on September 8, 1900.