Multiple choice

Isocitric acid is converted into 2-Oxoglutaric acid by the process of

  1. oxidative decarboxylation

  2. oxidative carboxylation

  3. dehydrogenation

  4. decarboxylation and hydrogenation
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A Correct answer
Explanation

Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate (alpha-ketoglutarate) in the citric acid cycle. This reaction removes a carboxyl group (decarboxylation) and involves NAD+ reduction (oxidative). The enzyme requires Mn2+ or Mg2+ as cofactor.

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