Multiple choice

Which of the following enzymes is biotin dependent?

  1. Acetyl-CoA carboxylase

  2. Methylcrotonyl CoA carboxylase

  3. Propionyl-CoA carboxylase

  4. Pyruvate carboxylase

Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

Propionyl-CoA carboxylase catalyses the carboxylation reaction of propionyl CoA in the mitochondrial matrix. The enzyme is biotin dependent. The product of the reaction is (S)-methylmalonyl CoA. Propionyl CoA is the end product of metabolism of odd-chain fatty acids and is also a metabolite of most methyl-branched fatty acids.

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