Thrombolysis is the breakdown of blood clots formed in the heart by pharmacological means, and is commonly known as clot busting. Which among the following enzymes can be modified genetically to function as clot buster?

Streptokinase (Tissue Plasminogen Activator or TPA) is an enzyme obtained from the cultures of some haemolytic bacterium Streptococcus and modified genetically to function as clot buster. It has fibrinolytic effect. Therefore, it helps in clearing blood clots inside the blood vessels through dissolution of intravascular fibrin.