Multiple choice

Which of the following proteins regulates thin filament length during sarcomere assembly?

  1. Nebulin

  2. Actin

  3. Myosins

  4. Titin
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A Correct answer
Explanation

Nebulin is an actin-binding protein which is localized to the I-band of the sarcomeres in skeletal muscle. It is a very large protein (600-900 kDa) and binds as many as 200 actin monomers. Because its length is proportional to thin filament length, it is believed that nebulin acts as a thin filament ruler and regulates thin filament length during sarcomere assembly.

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