Multiple choice

Which kind of mutation is induced by base analog 5-bromouracil?

  1. Insertion mutation

  2. Transversion mutation

  3. Transition mutation

  4. Deletion mutation
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C Correct answer
Explanation

5BU induces transition mutation in DNA. When a nucleotide containing 5-bromouracil is incorporated into the DNA, it is most likely to pair with adenine. However, it can spontaneously shift into another isomer which pairs with a different nucleobase, guanine. If this happens during DNA replication, a guanine will be inserted as the opposite base analog. This results in a change in one base pair of DNA, specifically a transition mutation.

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