To locate epistemology, to tie it to particular historical, political contexts, does not require its ________; it only requires a new and wiser self - understanding.

'Epistemology' is the study or theory of the nature, source and limits of knowledge. Therefore, the blank must be replaced by a word that is in opposition to the phrase - 'new and wiser self-understanding' - in the end of the statement. Let's scrutinize each option: 'Vandalism' in (1) - malicious or ignorant destruction of public or private property; as this is irrelevant, hence option (1) is ruled out.   'Expedience in (2) - desirable, advisable; which is contrary to our prediction, hence is ruled out.   'Indentation' in (4) - imprint, impression; which is contrary to our prediction, hence is ruled out. 'Scouring' in (5) - cleaning; which is irrelevant, hence is ruled out. 'Eradication' in (3) - to get rid of; destroy; which fits our prediction, hence the answer.