Multiple choice

Which of the following diseases in the newborn is not a manifestation of maternal IgG antibody crossing the placenta?

  1. Myaesthenia gravis

  2. Malar rash

  3. HIV infection

  4. Thyrotoxicosis

  5. Haemolytic disease of the newborn (rhesus)
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C Correct answer
Explanation

HIV infection is due to transmission of the HIV virus, not the antibody. However, the presence of maternal anti-HIV IgG can lead to diagnostic difficulty. It is therefore necessary to confirm HIV infection in the newborn by the presence of viral DNA or RNA using a polymerase chain reaction (PCR) method.

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