Multiple choice Directions: In which year given discovery/invention was made: Vaccination 1882 1880 1912 1796 Reveal answer Fill a bubble to check yourself D Correct answer Explanation Edward Jenner developed the smallpox vaccine in 1796 after observing that milkmaids who had cowpox seemed immune to smallpox. He tested his theory by inoculating a young boy with cowpox material, establishing the principle of vaccination.