Theology is the systematic study of religion, religious beliefs, and the divine. 'Sacrilege' means disrespect or violation of sacred things, which represents a conceptual opposite to the reverent study of the divine. However, this pairing is imperfect - more direct antonyms might be secularism or atheism. Among the given options, sacrilege is the closest in representing opposition to religious matters, though it's not a perfect lexical antonym.