Multiple choice

An evaluation of efficacy of a new vaccine against M. tuberculosis is best done using which of the following markers?

  1. Clinical evaluation of infection incidence in the field post-completion of an immunization programme of susceptible individuals

  2. In vivo IgM antibody responses

  3. In vivo IgG responses

  4. Quantification of Ag-specific T-cells by ELISPOT

  5. Quantification of Ag-specific T-cells by flow cytometric-based intracellular cytokine staining assay
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A Correct answer
Explanation

Clinical evaluation of infection incidence in the field post-completion of an immunization programme of susceptible individuals provides the most important evidence of efficacy. Such data may take 2 or 3 years to be collected, depending on the periodicity of infection with the organism. Long term immunity data is collected over 25 years to check that the provoked immunity is life-long (especially in these days of longer life spans).

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