Which one of the following is the main culprit in the thinning of ozone layer in the earth's upper atmosphere?

Chlorofluorocarbons (CFCs) are the primary chemicals responsible for ozone layer depletion, used historically in refrigeration, air conditioning, and aerosols. When they reach the stratosphere, UV radiation breaks them down, releasing chlorine atoms that catalytically destroy ozone molecules. Carbon dioxide, nitrogen, and oxygen do not cause ozone depletion.