Papain is a proteolytic enzyme belonging to cysteine protease family. Papain is found in unripe papaya and also in mountain papaya. Papain has a sulfhydryl group required for enzyme activity and a polypeptide chain accompanied by 3 disulfide bridges. Papain can digest protein substrates. Bromelain is a combination of proteolytic enzyme and small amounts of other substances like acid phosphatase, peroxidase, calcium and protease inhibitors. Bromelain is obtained from both stem and fruit of pineapples. Bromelain has anti-inflammatory effects and interferes with slow blood clotting.