Multiple choice

Which of the following acids is the precursor for pencilllin G biosynthesis during fermentation process?

  1. Phenylacetic acid

  2. Phenoxyacetic acid

  3. Acetic acid

  4. None of these

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A Correct answer
Explanation

During Penicillin G fermentation, Penicillium chrysogenum incorporates phenylacetic acid (or its precursor phenylacetamide) into the penicillin nucleus, forming the characteristic benzyl side chain of Penicillin G. This precursor addition is essential for biosynthesis. Phenoxyacetic acid is used for Penicillin V, and acetic acid is not a penicillin precursor.