Multiple choice

Match the following and choose the correct combination.

 
Group I Group II
A. BLOSUM 1. Margaret Dayhoff
B. Point accepted mutation 2. Samul Karim and Steven Altshul
C. FASTA 3. Henikoff and Henikoff
D. BLAST’s statistical theory 4. David J Lipman and William R. Pearson

  1. A - 3, B - 1, C - 2, D - 4

  2. A - 3, B - 1, C - 4, D - 2

  3. A - 1, B - 3, C - 4, D - 2

  4. A - 2, B - 4, C - 1, D - 2
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

BLOSUM matrices were developed by Henikoff and Henikoff for protein sequence alignments (A-3). PAM (Point Accepted Mutation) matrices originated from Margaret Dayhoff's work (B-1). FASTA, the first widely used sequence alignment tool, was created by David J. Lipman and William R. Pearson (C-4). BLAST's statistical foundation was developed by Samuel Karlin and Steven Altschul (D-2).

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