Multiple choice

Class switching takes place in ____ .

  1. the Pro-B cell

  2. the Pre-B cell

  3. immune B cell

  4. activated B cell

  5. plasma cell
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Activated B cell. Class switching is a process by which the isotype of the Abs produced in response to an Ag change as the humoral response proceeds. Different cytokine is induced switching to different antibody classes, enabling the immune system to respond in the most effective ways to different types of microbe. Activated (mature) B cell IgM+ IgD undergoes class switching by induced recombination of switch (S) region such that the VDJ primary RNA is spliced onto the RNA from the downstream C gene, producing a heavy chain with a new constant region and therefore a new class of Ig.

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