Multiple choice

Philadelphia chromosome is generated by translocation between

  1. chromosome 18 and chromosome 6

  2. chromosome 22 and chromosome 9

  3. chromosome 22 and chromosome 3

  4. chromosome 16 and chromosome 4

Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

The Philadelphia chromosome is formed by a reciprocal translocation between chromosome 9 and chromosome 22, specifically t(9;22)(q34;q11). This creates the BCR-ABL fusion gene associated with chronic myeloid leukemia. The other chromosome pairs listed are involved in different translocations.