Multiple choice Epimerism is an isomerism that occurs depending on whcih of the following? Presence of asymmetric carbon atom. Spatial orientation of groups of single carbon atom. Orientation of H-OH group in C1 and C4. Rotation of plane of polarized light. Spatial arrangement of groups in asymmetric carbon atoms. Reveal answer Fill a bubble to check yourself B Correct answer Explanation Difference in spatial orientation of groups on a single asymmetric carbon of a molecule having more than one asymmetric carbon. For example, glucose and galactose are 4 epimers of each other differing with respect to groups on C4.