Multiple choice

At cellular level, which of the following cells are primarily responsible for specificity?

  1. Cytotoxic T cells

  2. Hypervariable regions in domains of B cells

  3. The major histocompatibility complex

  4. Specific T cell receptors
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B Correct answer
Explanation

The hypervariable regions in the variable domains of antibodies (produced by B cells) are directly responsible for antigen specificity. These complementarity-determining regions (CDRs) form the antigen-binding site. While T cell receptors and MHC molecules are involved in immune recognition, the antibody hypervariable regions are the primary source of specificity at the molecular level.

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