Directions: In the following question, four statements are provided between an opening statement 1 and a closing statement 6. The four statements are jumbled up and form a coherent paragraph when properly arranged. Select the alternative representing the proper and logical sequencing of these six taken together.

(1) Charaka observes how these edible and potable substances can be rendered harmless. (A) He stated that the way in which they are combined with other foods also matters a lot. (B) Also, the way they are cooked affects the quality. (C) He arrived at his conclusions after a careful study of the facts. (D) Hence, care must be taken before mixing them. (6) Further, the mental state in which they are consumed is not insignificant.