Which of the given antibiotics can inhibit the transpeptidation reaction of peptidoglycan synthesis?
Transpeptidation is a reaction involving the transfer of one or more amino acids from one peptide chain to another.
-
Sulfonamides
-
Polymyxin B
-
Penicillin
-
Valinomycin
-
Gramicidin
C
Correct answer
Explanation
Some antibacterial drugs, such as penicillin interferes with the production of peptidoglycan by binding to bacterial enzymes known as penicillin binding proteins or transpeptidases. Penicillins inhibit the transpeptidation reaction and block cross-linking of the cell wall. This results in lysis of the cell wall due to high internal osmotic pressure.