Multiple choice Which of the following immunoglobulins mediates Type I hypersensitivity? IgA IgG IgM IgE Reveal answer Fill a bubble to check yourself D Correct answer Explanation It is also called anaphylactic, IgE or regain-dependent hypersensitivity. In this, the cytotropic IgE antibodies, are fixed on surface of cells like mast cells and basophils.