Multiple choice The maximum acceptable dose of lidocaine is 4.4 mg/kg when not accompanied by a vasoconstrictor 7 mg/kg when accompanied by a vasoconstrictor 12.2 mg/kg when accompanied by a vasoconstrictor both 1 and 2 Reveal answer Fill a bubble to check yourself D Correct answer Explanation Lidocaine undergoes biotransformation in the liver but in toxic doses, it first produces stimulation then depression of the CNS. In toxic overdose cases, convulsions may be induced, hypotension and cardiovascular collapse and respiratory arrest.