While playing Mudit accidentally ingested a chemical and presented with high fever. The chemical is known to affect ATP formation in electron transport chain. Which of the following could cause similar manifestations?
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Rotenone
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2,4-Dinitrophenol
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Antimycin A
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Cyanide
B
Correct answer
Explanation
It is a chemical uncoupler of electron transport and oxidative phosphorylation. It permeabilizes the inner mitochondrial membrane to protons, killing the proton gradient . In this situation, electrons continue to pass through the electron transport system and reduce oxygen to water, but ATP is not synthesized in the process thus it produces similar manifestations as given in the above question.