Multiple choice

Michael J. Fox, a well famed Canadian pop singer, has a hypokinetic disorder of the basal ganglia, Parkinson's disease. This disease is due to loss of

  1. dopamine in the putamen

  2. dopamine in the caudate nucleus

  3. gamma-aminobutyric acid (GABA) in the caudate nucleus

  4. gamma-aminobutyric acid (GABA) in the putamen

  5. dopamine in the substantia nigra
Reveal answer Fill a bubble to check yourself
E Correct answer
Explanation

Yes, it is correct. The loss of dopamine input from the substantia nigra to the striatum produces an imbalance in the indirect pathway versus the direct pathway of basal ganglia regulation. 

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