Which of the following could replace 'malfunction' as used in the passage?

Directions: Read the following passage carefully and select the most suitable option according to the corresponding number in the passage.

Kidneys are considered "vital organs," meaning they perform functions essential to your health. Your kidneys purify your blood. The filtered-out waste and water are called urine. The most common causes of kidney malfunction are diabetes and high blood pressure. Some kidney diseases are hereditary. If your family has a history of any kind of kidney problems, mention them to your health care provider. You might be at risk. As the disease progresses, you might notice you're urinating more or less frequently. You might feel queasy or lose your appetite. Some people experience numbness or swelling in the hands or feet. Others have muscle cramp. You might feel drowsy or have a difficult time concentrating.