Multiple choice

Which of the following statements about proto-oncogenes is true?

  1. They are originally derived from DNA tumor viruses.

  2. Loss of function mutations tend to occur in tumor cells.

  3. Mutation underlies most cases of familial predisposition to cancer.

  4. Some are activated by gene amplification.
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Proto-oncogenes are normal cellular genes that, when activated by mutation, contribute towards the malignant phenotype. Gene amplification is a mechanism of proto-oncogene activation.

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