Multiple choice

'De novo synthesis' signifies the synthesis of complex molecules from simple molecules. Which of the following chemotherapeutic agents works by impairing de novo purine synthesis?

  1. Acyclovir

  2. 5-fluorouracil

  3. Methotrexate

  4. Hydroxyurea
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C Correct answer
Explanation

Methotrexate works by inhibiting an enzyme known as dihydrofolic acid reductase,  which is important for transforming an inactive form of folic acid into the active form, which is necessary to make some of the building blocks needed for DNA production. It inhibits the synthesis of DNA, RNA and proteins.

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