Pancreatic juice secretion is regulated by two key hormones. Secretin, produced by S-cells in the duodenum when acidic chyme enters, stimulates bicarbonate secretion to neutralize acid. Cholecystokinin-pancreozymin (CCK-PZ), produced by I-cells when fats/proteins are present, stimulates digestive enzyme secretion. Gastrin primarily stimulates HCl secretion, while enterogastrone inhibits gastric motility.