Multiple choice

Which of the following amino acids acts as precursor to hormones epinephrine, norepinephrine and dopamine?

  1. L-2-Amino-3-(4-hydroxyphenyl)propanoic acid

  2. 2-Amino-3-hydroxybutanoic acid

  3. (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid

  4. Pyrrolidine-2-carboxylic acid

  5. 2-Amino-3-phenylpropanoic acid
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A Correct answer
Explanation

In dopaminergic cells in the brain, tyrosine (L-2-Amino-3-(4-hydroxyphenyl)propanoic acid) is converted to l-dopa by the enzyme tyrosine hydroxylase (TH). TH is the rate-limiting enzyme involved in the synthesis of the neurotransmitter dopamine. Dopamine can be converted into norepinephrine and epinephrine.

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